The aims of this work is to characterize the physico-chemical characteristics of grape varieties and wines from the wine region of Moldova under current climate change conditions. The musts from the varieties Busuioaca de Bohotin, Fetească neagră, Muscat Ottonel and Pinot gris showed values of sugars between 198 g / L and 254 g / L, acidity 5.04 g / L H2SO4 and 7.92 g / L H2SO4, the total nitrogen was between 0.91 g / L and 1.54 g / L. The wines obtained were characterized by alcohol concentration and sulfur dioxide with values falling within standards, total acidity on average lower than the musts with one unit, and the dry nonreducing extract ranged from 22.1 g / L to 32, 4 g / L. It has been found that climate change, especially rising temperatures, leads to an accumulation of sugars and extract in musts and wines from the Moldova Vineyards.